Vitamin C in ampoules for prophylaxis. Ascorbic acid in ampoules

Structure

1 ml contains an active substance: ascorbic acid - 50.0 mg or 100.00 mg.

Pharmacotherapeutic group

ATX code

pharmachologic effect

Ascorbic acid (vitamin C) is not formed in the human body, and comes only with food. Physiological functions: is a cofactor of some hydroxylation and amidation reactions - transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues pierced with the formation of hydroxyproline and hydroxylizin (post-transmission modification of collagen), oxidation of lysine's side chains in proteins to form hydroxitrixtillizin (in the process of carnitine synthesis), oxidation of folic acid to folin, metabolism of medicines in liver and hydroxylation microscopes Dopamine with the formation of norepinephrine. Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and Holicystokinin. Participates in steroidogenesis in adrenal glands. The main role in the fabric level is to participate in the synthesis of collagen, proteoglycans and other organic components of the inlet of the teeth, bones and endothelium of capillaries.

Indications for use

Treatment of hypo- and avitaminosis with (if necessary, quickly replenishing vitamin C and the impossibility of oral administration). It is used for therapeutic purposes in all clinical situations associated with the need for additional administration of ascorbic acid, including: parenteral nutrition, diseases of the gastrointestinal tract (peach diarrhea, delicate intestinal relavation, peptic ulcer, gastrectomy), Addison disease. In practice: for the marking of red blood cells (together with sodium chromat).

Contraindications

Hypersensitivity, with long-term use in large doses (more than 500 mg) - diabetes mellitus, hyperoxalura, nephrowolithiasis, hemochromatosis, thalassemia, glucose-6-phosphate dehydrogenase deficit.

Method of application and dose

Intramuscularly, intravenously (slow). Adults - from 100 to 500 mg (2-10 ml of 5% solution) per day, with zing therapy - up to 1000 mg per day. Children - from 100 to 300 mg (2-6 ml of 5% solution) per day, with zing therapy - up to 500 mg (10 ml of 5% solution) per day. The duration of treatment depends on the nature and course of the disease. For the marking of erythrocytes (together with sodium chromat) - 100 mg of ascorbic acid is injected into the bottle with sodium chromat.

Form release

The solution for intravenous and intramuscular administration is 50 mg / ml, 100 mg / ml. 1 ml or 2 ml in ampoules of colorless neutral glass Type I with a color ring of a break or with a color point and a notch or without a rings of a break, a color point and notches. One, two or three colored rings and / or two-dimensional barcodes, and / or alphanumeric encoding or without additional color rings, two-dimensional barcode, alpuning can be applied to the ampoules. 5 ampoules in the contour cellular packaging from the film of polyvinyl chloride and foil aluminum lacquered or polymer film or without foil and without a film. Or 5 ampoules in a pre-made form (tray) from cardboard with cells for styling ampoules. 1 or 2 contour cellular packs or cardboard trains along with the instructions for use and scarifier or an ampumen knife, or without a scarifier and an ampoule knife are placed in cardboard packaging (pack).

Ascorbic acid or vitamin C is known even to the child. Almost everyone knows that this vital element needs the body to maintain immunity, preventing colds and viral diseases. An excellent prophylactic tool is tea with lemon, citrus and berries, which includes vitamin. But the ascorbic acid can not enter the body can not only from food, but in the form of special drugs. Today, pharmacological companies offer vitamin C in ampoules. Thanks to this form of release, after the injection, the drug quickly enters blood and is characterized by a large effect. In addition, it is widely used in cosmetology.

In contact with

The benefits of ascorbic acid

Very important for the human body vitamin is organic substancewhich takes part in most vital processes:

Finding into the blood of a person with food or as drugs, ascorbic acid is immediately included in all metabolic processes. If it is not enough in the body, many vital processes begin to suffer.

However, the vitamin cannot be abused and uncontrolled. The drug is able to disrupt the integrity of the stomach and heat the kidneys. That is why experts recommend saturate the body with vitamin C through injections. Ascorbic acid injections in the right doses will help the body and will not harm the gastrointestinal tract.

pharmachologic effect

With the introduction of ascorbic acid intramuscularly or intravenously , it is easy, quick and just absorbed. In the body of its transportation, platelets and leukocytes are engaged. If we compare with plasma of blood, then in them the concentration of vitamin 30 times more.

The metabolism of the drug is produced by the liver. It concentrates in the muscles and lungs, hypophysies and brain, kidneys and genital organs, liver and pancreas. Displays vitamin with feces and urine from the body.

Indications for use

Vitamin C produced in ampoules as injections applied for the following states and pathologies:

Contraindications

Despite the greater benefit of ascorbic acid for the body, in certain diseases of it application is contraindicated:

Instructions for the use of ascorbic acid in ampoules

To avoid negative consequences, vitamin C injections should be made strictly in the dosage, which is indicated in the instructions.

Ascorbic acid is intravenously entered both inkjet (within 2-3 minutes) and drip (25-30 drops per minute). With drip administration as the basis, they take from 50 to 100 ml of 0.9% of the physiological solution or a 5% glucose solution.

With intramuscular administration The solution is preheated to room temperature, after which they are gained into the syringe and enter the needle deep into the thickness of the muscle. For injections use 5% solution of the drug.

For the treatment of diseases, adults is prescribed from 1 to 5 ml of vitamin one - three times a day. For children, the daily dose of 5% of the drug is 0.6-1.0 ml. The course of treatment depends on the state of the patient and the neglence of the disease.

Injections of ascorbic acid in ampoules must be appointed after the examination conducted by the attending physician.

special instructions

Since one of the key actions of ascorbic acid is the synthesis of corticosteroid hormones, then when overdose is possible risk of renal stones. Therefore, treatment with this vitamin should pass under the control of the kidneys, adrenal glands and blood pressure.

With caution, the drug should be used with a high iron content in the blood.

The excess of the vitamin rate can lead to a decrease in the operation of the inusular apparatus of the pancreas.

Side effects

In most cases, ascorbic acid patients are moved well, however, in the process of receipt of the drug some side effects are possible:

1. In case of rapid injection injection - dizziness and fatigue.
2. With intramuscular administration - painful sensations in the injection site.
3. With overdose - headaches and increased excitability.
4. Growing blood pressure due to the deterioration of permeability of capillaries.
5. With prolonged reception and a dose being exceeded - a disorder of the kidneys, the development of nephrolithiasis or moderate Pollakiuria.
6. In patients prone to allergies, allergic reactions are possible, and even anaphylactic shock.
7. Development of hypoprothrombinemia, glucosuria, leukocytosis, thrombocytosis, erythrogenic.

Storage conditions and prices

Ascorbic acid in ampoules should be stored At air temperature from +5 ° C to +15 ° C in direct sunshine-protected place. The drug should be unavailable for children. The shelf life of vitamin for injection is from one and a half to two years.

It is ascorbic acid inexpensive. The price per pack of 10 ampoules in 2 ml of 5% of the solution is only about 30 rubles.

Ascorbic Face Acid

Proved that vitamin C is positive effect on the skinTherefore, the solution produced in ampoules has long been applied in cosmetology.

The correct use of ascorbic acid feeds the skin and eliminates its redness and peeling, updates the cells, improves the complexion.

To maintain the skin of the face in the normal state, fueled and refreshing it, the following procedure is recommended:

1. Two ampoules of the drug breed with boiled water temperature in a 1: 1 ratio.
2. The resulting solution wipe the face, neck and zone with neckline in the morning and in the evening after water procedures.
3. If after applying the solution, a feeling of burning appears, then you must add another portion of water.

Excellent effect can be achieved if you use a mask consisting of vitamins C, E, A. The solutions are mixed and applied to the skin. Strengthen the effect of mask combining ascorbic acid and fresh fruit.

To remove cosmetic defects and improving the appearance of skin professional cosmetologists carry out mesotherapy. During such a procedure, with a very thin needle, a special preparation containing vitamins is introduced under the skin. Ascorbic acid injections are powered and protected from free cell radicals, contribute to improved blood circulation, render whitening effect. Trust such therapy follows only verified and certified specialists.

Vitamin C is one of those components that are vital to the body. In large quantities, vitamin is contained in berries and citrus fruits. Pharmacies offer funds that resemble yellow pills with sourness from childhood. Their effectiveness is insignificant, in comparison with intramuscular administration. Ascorbic acid in ampoules instantly penetrates the circulatory system and useful substances are spread throughout the body.

The benefits of ascorbic acid

The substance accelerates the recovery and establishes the exchange processes of the human body. White or yellow tint powder has an acidic taste, remarkably dissolved in water. Thanks to the useful qualities of vitamin C, the drug is opposed to various diseases and enhances protective functions. One portion of the means has the following impact:

• strengthens the immune system;
• cites the level of cholesterol;
• reduces the likelihood of diseases of the respiratory system;
• improves the chemical composition of blood due to the saturation of hemoglobin;
• tits skin cover, promotes the rapid regeneration of cells.

When using ascorbic acid, an accurate dosage prescribed by the attending physician should be observed. Otherwise, a number of side effects will arise, including violation of the functioning of the digestive system and damage to the gastric walls. Plus, an excessive amount of vitamin C loads the excretory system.

pharmachologic effect

The human body does not produce ascorbic acid independently, the required component gets along with food. It takes part in metabolic processes, restoration, oxidation, regeneration, normalization of blood clotting. The presence of vitamin C allows to exhibit stability before infections, as well as the substance establishes the permeability of capillaries, strengthens the vascular walls, reduces the lack of other vitamins.

The tool exhibits an antioxidant effect that provides hydrogen transportation for the absorption of glucose and the successful implementation of important biochemical processes, such as the synthesis of collagen elements and hormones from the steroid group.

Ascorbic acid with intramuscular administration is combined with plasma proteins, after 4 hours after entering the blood, the concentration of the substance reaches its maximum. The component quickly penetrates the tissue along with platelets and leukocytes, accumulating in the organs. Suction is carried out in a small intestine, where vitamin is transformed into dehydroasorbic acid.

Intestine and kidneys are responsible for the output of metabolites, some of the body disappears from the organism and then both breast milk. It is important to take into account that alcoholic beverages and tobacco products provoke a change in ascorbic acid. Reserves of substances in the body are reduced due to its transformation into inactive type metabolites.

When to use

Experts recommend to increase the dose of ascorbic acid naturally, that is, through food, but sometimes it is impossible to do it, especially in the winter season. The introduction of ascorbic acid intravenously and intramuscularly is assigned in such cases:

• the elimination of avitaminosis and hypovitaminosis of ascorbic acid, when oral use is impossible, and the need for an urgent replenishment of the substance is present;
• with problems with the functioning of the digestive system;
• in case of chemical poisoning by gaseous substances, in this case an ascorbinka normalizes oxidation and restores the inner medium of the body, which is important when removing toxic elements.

These challenges need to contact a medical institution where a specialist is an individual treatment plan based on the results of diagnostic measures.

Indications for use

Attention should be paid to the first symptoms of hypovitaminosis, which manifest themselves as paleting the skin, disorders of regeneration, weakness, insomnia, weakened immunity, the bleeding of the gums. Vitamin C in ampoules for injection is used in the following situations:

• long-term supercooling of the body;
• irrational nutrition;
• in the presence of dangerous diseases, such as qing and tuberculosis;
• prolonged physical and mental stress;
• recovery period after surgical intervention or protracted treatment;
• therapy against dependence on alcohol and tobacco products;
• abundant bleeding;
• intoxication of the body;
• liver disease;
• hemorrhagic diathesis;
• problems with the functioning of respiratory organs;
• dystrophy.

In each case, the dosage and reception regularity is determined individually. Sometimes it is possible to get rid of oral administration, but in certain cases injections are prescribed.

special instructions

A continuous lack of ascorbic acid causes irreversible changes in the body. These include:

• the emergence of secondary infectious diseases;
• excessive mobility or loss of teeth;
• the tendency of bones to fractures;
• problems with the work of digestive, cardiovascular, excretory systems;
• abundant bleeding;
• pain sensations in muscles and joints, which significantly limits mobility.

Clinical manifestations of the deficit lead to the appointment of vitamin C injections to avoid negative consequences, with injections, strict dosage and regularity should be observed. Ascorbic acid is introduced into the blood of the stake (for 2-3 minutes) or drip (25 drops per minute). In the first case, the basis of the means is saline (0.9%) or a solution of glucose (5%), in an amount of 50-100 ml. Droppers with ascorbic acid are used in serious diseases.

Before intramuscular use, the drug is heated to ambient temperature (about 23 degrees), then filled with a syringe and introduced a working solution from ascorbic acid directly into muscle tissue. For injections, a solution of 5% is intended. Adults are assigned to the reception of vitamin three times a day of 1-5 ml. In childhood, the dose decreases to 1 ml. The treatment plan directly depends on the stage of illness and the condition of the body.

Due to the fact that ascorbic acid leads to the development of corticosteroid hormones, the likelihood of the formation of congregations in the kidneys increases. That is why therapy is carried out with regular diagnosis of adrenal glands, kidneys and pressure in the circulatory system. With an excessive level of iron in the body, it is necessary to approach with extreme caution. An increase in the content of vitamin C leads to a violation of the pancreas.

Side effects

The use of vitamin C in ampoules requires compliance with some rules. As a rule, ascorbic acid is perfectly perceived by the body, but under a number of factors, side effects arise, which include:

1. Lost and dizziness, which is a consequence of the rapid administration of a solution of ascorbic acid.
2. Pain in the zone of intramuscular injection.
3. Excessive excitability and frequent migraines in overdose.
4. Increased arterial pressure due to capillary permeability.
5. Allergic reactions with individual intolerance of the component.
6. Thrombocytosis, leukocytosis and glucosuria.
7. Lack of adrenal cortex.

With any of these factors, it is necessary to stop receiving the means and consult with the attending physician. Otherwise, severe complications and secondary diseases are developing. Before pricking vitamin C, it is necessary to be convinced of the absence of individual intolerance.

Is an overdose possible?

Overdose is a consequence of a negligent attitude towards the treatment of ascorbic acid. This often occurs when the patient moves to independent or home administration of injections. Therefore, patients are recommended not to abandon therapy in outpatient conditions. Signs of dose exceeding are:

• hyperglycemia;
• arterial hypertension;
• thromboembolia;
• elevated blood sugar;
• the formation of concrections.

These problems arise not only in overdose, but also in the case of long-term treatment. In any case, it is necessary to stop receiving the funds and tell the doctor about the problems that have arisen.

Compatibility with other drugs

Ascorbic acid is not recommended to be used with preparations, which in its composition have folic acid, iron, vitamin B12. Their combination leads to undesirable consequences, and in long-term therapy develop serious side effects and diseases.

Contraindications

Ascorbic acid in the form of injections, like another drug, has some contraindications. According to the instructions, their number includes:

• individual intolerance to acid;
• diabetes;
• conditions in the excretory system;
• blood coagulation disorders;
• pregnancy and lactation;
• thrombophlebitis or a tendency to the formation of thromboms.

Different preparations are used in the treatment of respiratory diseases. In a complex with antimicrobial, vesseloring, mulitics and other means, patients prescribe medications that increase the resistance of the body and improving the flow of metabolic processes. Such is primarily ascorbic acid. All information about it, which is worth paying attention to is set out in the instructions for use.

Ascorbic acid (it is vitamin C) is a substance of a crystal structure as a white powder. It is well soluble in water, and in other liquids (alcohol, glycerin) is much worse. Powder has sour taste, stable in air. But the aqueous solutions with oxygen contact quickly darken. For medical purposes, they are produced in ampoules with different concentrations of the active substance (5 and 10%), 1 or 2 ml.

Act

Vitamin C plays very important in metabolic processes - metabolism of proteins, fats and carbohydrates, hormone synthesis, collagen, blood coagulation. Ascorbic acid has antioxidant properties and inhibits the selection of prostaglandins, helping to fight inflammation. It normalizes the permeability of the vascular wall and has antiallergic properties: accelerates the collapse of the histamine, inhibits the synthesis of anaphylaxia mediators. The medicinal substance activates the enzyme system of the liver for detoxification of harmful substances in the body. Thanks to the improvement of tissue metabolism, wound healing and other damage is accelerated.

Vitamin is actively involved in immunological reactions at the local and systemic levels, increasing the resistance to infections. Ascorbic acid is capable of activating the formation of antibodies, antiviral protein (interferon), components of the complement system. Under its influence, the need for other vitamins (thiamine, tocopheropole, routine, folic and pantothenic acids) is reduced, the function of the pancreas and thyroid glands is normalized. All of the above makes a solution of ascorbic acid very popular with infectious diseases of the respiratory tract.

Vitamin C has a very wide range of biological action. The effects of ascorbic acid are multifaceted and extremely important for the normal functioning of the body.

Distribution in the body

After parenteral administration, ascorbic acid 5% quickly penetrates blood with the achievement of maximum concentration. The fourth part binds to plasma proteins. Vitamin easily penetrates all the tissues of the body, especially ferrous. Metabolism mainly occurs in the liver. Excretion is carried out in various ways: through the kidneys, intestines, with then, female milk. The destruction of ascorbic acid is intensified during smoking and alcohol abuse.

Indications

Considering the comprehensive effect of the drug, its scope is very wide. Ascorbic acid in ampoules is prescribed at the following states:

• Infectious diseases.
• Various intoxication.
• Hemorrhagic diathesis.
• Bad healing wounds and ulcers.
• Hypovitaminosis C.
• Liver disease.
• Bleeding.
• Distrophic processes, etc.

The drug is widely used in patients with respiratory diseases. He speeds up recovery and warns the re-development of infection.

Application

Any medicine, including ascorbic acid, should be appointed by a doctor. Only a specialist may establish the feasibility of using the drug, determine the most appropriate dosage (how many percent and ampoules) and the optimal duration of treatment.

Method of reception

Ambula ascorbins are designed for parenteral administration, i.e., into the trafficking of the gastrointestinal tract. The solution is used with intramuscular or intravenous injections. One-time and daily dose depends on the content of vitamin in ampoule. 5% solution is introduced in 1-3 ml, and more concentrated - 1 ml. The instructions indicate the maximum dosages of the drug. Translated by a 10% solution, they correspond to 2 and 5 ampos (respectively, at once and a day).

Side effects

The use of acid ascorbin in ampoules is sometimes associated with a negative impact on the body. The synthesis of insulin and glycogen can be observed, which entails increasing blood glucose and its detection in the urine. In addition, the list of side effects in the injection injection of the drug includes:

• Neriva-mental disorders (weakness and dizziness).
• Allergic reactions (rash and redness of the skin).
• Hematological disorders (raising platelets and neutrophils, reduction of red blood cells and prothrombin).
• Local manifestations (soreness at the place of administration).

Changes in metabolism, in addition to glycemia and glucosuria, include fluid and sodium delay, potassium deficiency, enhanced glucocorticoid synthesis. The latter may cause an increase in blood pressure. If you enter intravenously large doses of ascorbins, that is, the risk of hemolysis of erythrocytes and interrupting pregnancy.

Despite the mass of the beneficial properties inherent in ascorbic acid, the drug can also give side effects.

Restrictions

Even the necessary organism substance like vitamin C, with incorrect use, may entail undesirable consequences. Therefore, before its purpose it is necessary to take into account all limiting factors. Related diseases or probable reception of other medicines are all importance to ensure safe and effective treatment.

Contraindications

As the instruction manuals testifies, among absolute contraindications, there are only hypersensitivity to ascorbic acid and a tendency to arterial thrombosis. With caution, the medicine is used in patients with diabetes mellitus, hypertension, urolithiasis, glucose-6-phosphate dehydrogenase deficit, hemolytic anemia. Injection forms of vitamin C During the period of the baby, the child is not prescribed without extreme need. This is due to the lack of convincing data on the absence of unfavorable effect on the fruit.

Interaction

Ascorbic acid in ampoules can interact with other medicines. It increases the blood concentration of salicylate, estrogen, corticosteroids, some antibiotics (tetracycline, benzylpenicillin). The activity of norepinephrine during co-use with vitamin C increases, but the effects of anticoagulants (heparin, warfarin) are reduced. Under the influence of ascorbic acid, the absorption of iron preparations in the intestine is improved. The solution cannot be mixed in one syringe with other medicines.

Ascorbic acid for injection administration is an effective drug that operates comprehensively. In respiratory diseases, it accelerates the patient's recovery and increases the organism resistance to infections. But the use of vitamin C must be coordinated with the attending physician.

Medical Instructions

drug

Ascorbic acid(vitamin C)

Tradename

Ascorbic acid (vitamin C)

International non-proprietary title

Ascorbic acid

Dosage form

Injection mortar 5%, 2 ml

Structure

2 ml of solution contain

active substanceso - Ascorbic acid 100.00 mg,

excipients: sodium bicarbonate, sodium sulphite anhydrous, water for injection.

Description

Transparent colorless or slightly painted liquid

Pharmacotherapeutic group

Vitamins. Ascorbic acid.

A11GA01 code

Pharmacological properties

Pharmacokinetics Ascorbic acid It is well distributed in the tissues of the body, penetrates the placental barrier and in breast milk. Communication with plasma proteins - 25%. The plasma ascorbic acid concentration is approximately 10-20 μg / ml. Easily penetrates leukocytes, platelets, and then in all fabrics; The greatest concentration is achieved in ferruginous organs, leukocytes, liver and leather leakage; Penetrates the placenta. The concentration of ascorbic acid in leukocytes and platelets is higher than in the erythrocytes and plasma. In deficient states, the concentration in leukocytes is reduced later and more slowly and is considered as the best criterion for estimating the deficit than the plasma concentration.

Metabolized mainly in the liver into the deoxyaskorbic acid and further in oxaluacetic acid and ascorbate-2-sulfate.

Examined by the kidneys, through the intestines, with then, breast milk in unchanged form and in the form of metabolites.

When prescribing high doses, the elimination rate is sharply enhanced. Smoking and use of ethanol accelerate the destruction of ascorbic acid (transformation into inactive metabolites), sharply reducing reserves in the body.

Derived during hemodialysis.

Pharmacodynamics

Ascorbic acid (vitamin C) is not formed in the human body, and comes only with food. Pharmacological effects: in quantities that significantly exceeding the daily need (90 mg), almost does not have actions, with the exception of the rapid elimination of the symptoms of hypo- and avitaminosis (zing). Physiological functions: is a cofactor of some hydroxylation and amidation reactions - transfers electrons to enzymes, providing them with a reducing equivalent. Participates in the reactions of hydroxylation of proline and lysine residues pierced with the formation of hydroxyproline and hydroxylizin (post-transmission modification of collagen), oxidation of lysine's side chains in proteins to form hydroxitrixtillizin (in the process of carnitine synthesis), oxidation of folic acid to folin, metabolism of medicines in liver and hydroxylation microscopes Dopamine with the formation of norepinephrine. Increases the activity of amidating enzymes involved in the processing of oxytocin, antidiuretic hormone and Holicystokinin. Participates in steroidogenesis in adrenal glands. The main role in the tissues is to participate in the synthesis of collagen, proteoglycans and other organic components of the intercellular substance of teeth, bones and endothelium capillaries.

Regulates immunological reactions (activates the synthesis of antibodies, the C3 component of the complement, interferon), contributes to phagocytosis, increases the body's resistance to infections. It slows down and accelerates the degradation of histamine, inhibits the formation of prostaglandins and other inflammation mediators.

Indications for use

Prevention and treatment of hypovitaminosis and vitamin C avitaminosis (qing)

Hemorrhagic diathesis, capillaryotoxicosis, bleeding (nose, after the extraction of teeth, pulmonary, uterine, caused by radial disease) as part of complex therapy

The increased need of the body in the period of growth, pregnancy, lactation, physical and mental loads

Reconnaissance period after transferred infectious diseases

and intoxication

Liver diseases (chronic hepatitis and cirrhosis) as part of comprehensive therapy

Chronic adrenal insufficiency (Addison disease),

addison's adrenal crisis

Hypoacid gastritis, ulcerative disease of the stomach and duodenum

guts, condition after stomach resection, enteritis, colitis

Sliding wounds and ulcers, bone fractures

Method of application and dose

Intravenously, intramuscularly (slow), adults from 100 to 500 mg (2 - 10 ml of 5%) per day, with zing therapy - up to 1000 mg per day.

Children under the age of 6 months are prescribed at 20-30 mg / day (0.4-0.6 ml of 5% solution), aged 6-12 months - 35 mg / day (0.7 ml of 5% solution), 1- 3 years - 40 mg / day (0.8 ml of 5% solution), 4-10 years - 45mg / day (0.9 ml of 5% solution), 11-14 years - 50 mg / day (1 ml of 5% solution ), For children over 15 years of 60-100 mg (1.2-2 ml of 5% solution) 1 time per day. For cing therapy in children - up to 500 mg (10 ml of 5%) per day.

In the treatment of an adrenal crisis, intravenously in 250-200 mg (5-10 ml of 5% solution) is slowly every 3-4 hours.

Side effects

- headache, feeling fatigue

Increased blood pressure, myocardiodestrophia

Infertility of the endocrine function of the pancreas (hyperglycemia, glucosuria)

Thrombocytosis, anemia, neutropyl, hypokalemia

Hyperprothrombinemia, thrombosis, reduction of capillaria permeability and deterioration of tissue trophic

Allergic reactions (including anaphylactic shock)

Violation of the kidney function (glomerulopathy), urolithiasis, the formation of oxalate stones

With prolonged use of large doses: Sodium delay and liquid, development of microangiopathy, zinc exchange violation, copper leading to neurotoxic effects (increase the excitability of the CNS, sleep disorder)

Contraindications

Hypersensitivity to the components of the drug

Hypercoagulation

Trombo, thrombophlebitis

Diabetes, hyperoxalaturia, nephrolithiasis

Hemochromatosis, Thalassemia

Glucose-6-phosphate dehydrogenase deficit

Carefully

Cideroblastic anemia

Medicinal interactions

The simultaneous use of aluminum containing antacids and ascorbic acid is not recommended, especially in patients with renal failure, as the elimination of aluminum through the kidneys may increase.
Increases the concentration of salicylates in the blood and increases the risk of oxalateuria.

Increases the absorption of ethinyl estradiol, tetracycline and penicillins.

Contributes to the absorption of iron and its deposit in restored form.

Ascorbic acid and combined oral contraceptives mutually reduce each other's concentration.

Barbiturates and prison amplify the excretion of ascorbic acid with urine.

In high doses, ascorbic acid increases the excretion of amphetamine and tricyclic antidepressants.

With simultaneous use with deferoxamin, its effect will potentiate and increases the excretion of iron.

Weakens the effects of indirect anticoagulants (phenindion, warfarin, neodykumarina) and heparin.

With long-term use of quinolone, calcium chloride, salicylates and glucocorticosteroids reduce the level of ascorbic acid in the plasma and its content in the body.

Smoking and ethyl alcohol accelerate the metabolism of ascorbic acid and reduce its content in the body.

special instructions

Since the drug is widely used as an aid, then the first signs of improved state depend on the nature and course of the disease and the effectiveness of treatment.

When used in large doses, the kidney functions and blood pressure are needed (stimulation of ascorbic acid formation of corticosteroids), as well as the function of the pancreas (inhibition of the insular apparatus).

The use of ascorbic acid in doses of over 500 mg / day can provoke hemolytic crisis in people with a deficiency of glucose-6-phosphate dehydrogenases, sickle-cell anemia, lead to the development of acute left-selling deficiency.

Special care is prescribed to patients with urolithiasis, it is not recommended to use large doses for a long time.

With caution, the drug should be prescribed during hypercoagulation, thrombophlebitis and thromboembolic states at present or a history.

Application in oncology

The use of ascorbic acid in high doses in patients with rapidly proliferating and widely dismissed tumors can be aggravated by the course of the process. Therefore, with caution to apply ascorbic acid in this group of patients.

Impact on laboratory indicators.

The use of large doses of ascorbic acid may affect the results of determining blood glucose levels and urine.

Pregnancy and lactation

Ascorbic acid penetrates the placenta and stands out with the chest

Features of the influence of the medicinal product on the ability to control the vehicle or potentially hazardous mechanisms

During the period of treatment, care must be taken when managing motor transport and occupation of potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Overdose
Symptoms:diarrhea, nausea, vomiting, abdominal pain pain

character, stripped urination, headache, nephrolithiasis, hypoglycemia, glucosuria, metabolic acidosis.

Treatment: Cancellation of the drug, symptomatic therapy, forced diuresis.

Release form and packaging

2 ml in the ampoules of neutral glass.

On each ampoule sticks a label paper label or text directly on an ampoule of paint deep printing for glass products.

5 and 10 ampoules are packaged in the contour cellular packaging of polyvinyl chloride and aluminum foil.

10 ampoules are placed in a cardboard box with a corrugated liner. The scarifier is invested in each packing.

Banderoli boxes or contour cellular packaging, together with approved medical instructions in public and Russian, are placed in cardboard boxes.

The number of instructions is embedded by the number of packages.

Storage conditions

Store in a dry place protected from light, at a temperature not higher than 25 0 S.

Keep out of the reach of children!

Storage term

After the expiration date, the drug does not apply.

Conditions of vacation from pharmacies

Without recipe

Manufacturer

JSC "Himfarm", Kazakhstan,

g.Symkent, st. Suradova, B / N, T / f: 560882

Owner of the registration certificate

JSC "Himfarm", Kazakhstan

Address of the organization hosting on the territory of the Republic of Kazakhstan consultations from consumers for product quality (product)

JSC "Himfarm", Kazakhstan,

g.Symkent, ul. Rashidova, b / n, t / f: 560882

Telephone number 7252 (561342)

Fax number 7252 (561342)

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