Etamsylate solution for intravenous and intramuscular administration of SCF. Etamsilat: instructions for use, analogues and reviews, prices in pharmacies in Russia Etamsilat in which case it is used

To combat bleeding, it is difficult to find a drug that is more effective and less hazardous to health, such as Etamsilate. The range of application of this hemostatic agent is very wide, the price is competitive. Therefore, most cases of bleeding cannot be treated without it.

Indications for use

The inclusion of Etamsilate in therapy is indicated for bleeding in almost any pathological situation. According to the instructions, Etamsilat is the best way to stop capillary bleeding of various etiologies. The drug is effective for heavy periods, it reduces the volume of menstrual flow. When your period is prolonged, medication will help stop your period.

In addition, indications for the use of Etamsilat are:

• lesions of the walls of blood vessels in diabetes;
• surgical interventions in dentistry, urology, ophthalmology, gynecology and other medical fields;
• diathesis, accompanied by vascular lesions;
• emergency cases, for example, if it is necessary to stop bleeding in the intestines, lungs, and other organs.

Composition and form of release

The choice of Etamsilat by most doctors is influenced by a wide variety of its dosage forms. These include Etamsilate tablets and injections. In each of these drugs, the active ingredient is Etamsylate. The injections additionally contain water and special sodium salts.

Etamsylate tablets contain 250 mg of active ingredient, an additive (sodium metabisulfite), calcium salts, starch, conventional binders. There are 10 or 50 tablets in a blister. When treating children, the drug is prescribed based on the weight of the child. The use of dosage forms in tablets allows you to adhere to a maximum dosage of 5 mg per 1 kg of body weight in a single dose.

Etamsilat injections are available in packs of 10. Ampoules of 2 ml of solution for injection contain 125 mg of active ingredient in each milliliter of the drug.

Features of the effect of Etamsilat

Due to the specificity of the pharmacokinetics of the drug, this agent is successfully used to stop menstruation. For these purposes, many women use Etamsilat tablets. The medicine affects the permeability and strength of both capillaries and large blood vessels, strengthening them and making them more elastic. The drug is neutral in terms of its effect on blood composition. But due to the activation of platelets after using the drug, the blood becomes more viscous.

Read also Byzanne and menstruation - cycle recovery

The drug does not increase the risk of blood clots and does not increase blood fibrinogen. At the time of the onset of the blood coagulation process, Etamsylate has no effect.

The effectiveness of this drug and its safety is facilitated by its positive effect on blood flow rate, improvement of blood microcirculation during its use. These features are the main reason why Etamsilate is prescribed for bleeding. Its action allows you to close the bleeding place in the vessel, but not disrupt the blood flow and supply of organs with it.

Application during pregnancy and lactation

As a rule, Etamsilate during pregnancy is necessary to eliminate the threat of miscarriage. But in the first trimester of pregnancy, injections of the drug are prescribed only when absolutely necessary, since there is a risk of harming the fetus.

For pregnant women in the second or more trimester, this medicine is not dangerous. In case of ectopic pregnancy, the drug is not used. In each of the cases, only the doctor determines how much during pregnancy, taking into account the composition of the blood and other indicators, the use of this remedy is justified.

Since Etamsilat is able to penetrate into breast milk, the drug is not prescribed during lactation.

Method of administration and dosage

When using Etamsilat, the instructions for use must be followed strictly. This manual is very accurate and clearly sets out all the conditions under which it is possible to use the medicine.

When prescribing tablets, the following dosage is observed:

• 0.25–0.5 mg of the drug 3-4 times a day with moderate bleeding during menstruation;
• 0.75 mg of the drug (3 tablets) from 3 to 4 times a day with extremely heavy periods;
• 0.5 mg up to 4 times a day, if necessary, to cope with profuse long periods; pills are taken 10 days, starting five days before the onset of menstruation.

With each oral administration, the tablets begin to take effect after about 20 minutes, the maximum effect will occur after 2 or slightly more hours.

The most effective are drug injections. It is administered intravenously and intramuscularly. In the first case, the effect appears almost before our eyes - in less than 10 minutes.

The dosage depends on the indications and is prescribed by the doctor. According to the instructions, when treating with Etamsilat injections, 0.125 to 0.250 mg of the drug should be administered at a time, the maximum dose is 0.375 mg. The number of injections is up to 4 times a day.

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In extreme cases, for example, with bleeding due to the installation of the spiral, it will be necessary to inject up to 6 ampoules per day.

The blood can be stopped with Etamsilat if there is an open wound. To do this, use a tampon soaked in the preparation or a sterile bandage.

Contraindications

Among the factors limiting the use of Etamsilat, first of all, diseases accompanied by the formation of blood clots are mentioned. The main contraindications include:

• vascular disease;
• thrombosis;
• thromboembolism;
• hemoblastosis;
• acute porphyria;
• hemorrhage (as a consequence of the action of anticoagulants);
• oncological diseases;
• individual intolerance.

Many women use Etamsilat during menstruation to reduce them unnecessarily, for example, when the discharge is of an average volume and lasts 5 days. The desire to reduce the duration of menstrual days to 3 days can lead to serious illness. Only a doctor should prescribe the drug.

Side effects

This drug has the following side effects:

1. Drop in pressure.
2. Headache.
3. Disorders of the stomach, heartburn.
4. Dizziness.
5. Skin rashes, irritation, itching.
6. Temperature increase

Overdose

The main treatment regimen does not imply an overdose. Therefore, no cases of exceeding the permissible doses of the drug were found.

In some cases, in the conditions when Etamsilat is used, it is necessary to take into account the possibility of its effect on the body. For example, during treatment with the drug, you should stop breastfeeding your baby.

Taking this medication in excessive doses does not require special measures. To eliminate the possible consequences, it is enough to cancel the drug. Almost all of the introduced amount is excreted by the kidneys, so within 3-4 days its content in the blood will no longer pose a threat.

Interaction with other drugs

As an indication of the interaction of Etamsilat with other drugs, the instructions for use require not to mix this drug with any other. It is better to use a separate syringe for this.

Etamzilat's analogs

If for some reason Etamsilat is not suitable for the patient, analogues can successfully replace it. A direct analogue of Etamsilat is the medicine Dicinon. It contains the same active ingredient.

Other drugs, which include substances belonging to other pharmacological groups, can also help cope with the problem of bleeding. Among them:

• Vikasol;
• Impedil;
• Ezelin;
• Cyclonamine;
• Aglumin and others.

If the patient wants to replace the currently used Etamsilate with one of the drugs, a specialist should select analogues.

The drug Etamsilat is a drug whose main purpose is to increase the rate of formation of carbohydrate, protein and polymer complexes in the capillaries. The drug helps to increase capillary permeability during reactions that form in the body when a pathogenic environment occurs, provoking the occurrence of failures in the normal course of life processes and protective reactions. Etamsylate normalizes blood, and also accelerates the process of stopping bleeding. The effectiveness of a drug is formed on the basis of its protein-lipid complex.

Pharmacological and pharmacokinetic properties

The pharmacology of the drug Etamsilat is due to such types of effects as hemostatic and angioprotective. The medication has a stimulating effect on the formation of platelets that leave the bone marrow. This medication promotes the activation of thromboplastin, which is formed in those places where small vessels show signs of damage. Thus, the degree of bleeding is reduced, which contributes to the acceleration of wound healing. Pharmacological properties can be characterized as follows:

• Stopping bleeding. The process of stopping bleeding is based on a decrease in the number of components that prevent platelet aggregation. In this way, the ability of platelets to adhere to the components of the epithelium increases, after which they stick together, thereby forming a thrombus at the site of damage.
• Formation in the capillary walls of carbohydrate-protein polymers contained in the carbohydrate part.
• Increasing the ability of capillaries to maintain their intactness in the event of mechanical damage.
• Increased signs of blood circulation.
• Restoration of indications of blood clotting.

The pharmacokinetic properties of the medication are due to a distinctive feature that manifests itself in the form of a high degree of absorption. With the introduction of a medication into the body, its equilateral distribution is carried out over all organs and tissues of a person. It is also important to note the fact that Etamsylate comes into contact with blood plasma proteins very weakly.

The agent is excreted from the body naturally through the kidneys and intestines. The elimination process is fast enough, so everything takes at least 4 hours. After intravenous administration of the drug, its activation is observed within 15-20 minutes. 2 hours after the administration of the medication, the maximum effect is achieved, which lasts for 6 hours. With intramuscular administration of the drug Etamsylate, the achievement of the maximum effect occurs no earlier than 3-4 hours later.

It should be noted that Etamsilat is produced in the form of injections and tablets. Tablets are convex round shapes, each pack containing 50-100 pieces. Etamsylate in the form of injections is a transparent solution with a shade of yellow. The solution is contained in ampoules, of which the package contains 1,2 or 10 pieces. The solution contains the main substance Etamsylate in an amount of 0.125 ml, as well as auxiliary components. These components in the composition of the solution include: disodium edetate, sodium disulfite, anhydrous sodium sulfite.

It's important to know! The composition of the drug should be known, since some patients may have signs of their intolerance to the body.

In what cases is the use of the medication indicated?

Etamsilat injections, as evidenced by the instructions for use, is shown to be used both for the prevention of provoking bleeding and for stopping them in the event of dangerous parenchymal bleeding. Such bleeding can occur both with the occurrence of lesions of internal organs, and with capillary damage.

It is indicated to apply to the use of a drug if the following factors are present:

• In case of traumatic bleeding.
• In dentistry, when removing teeth or cysts.
• In the urological area, when a prostatectomy occurs.
• In the field of ophthalmology, for the removal of cataracts.
• In the field of otolaryngology, when microsurgical operations are indicated.
• When internal bleeding occurs.
• With hemorrhages that occur in the brain.
• In case of an overdose of anticoagulants.
• With diathesis and vasculitis.
• With hemorrhagic disorders.

It is forbidden to use the drug without special indications and the appointment of a specialist, as it can lead to a blood clot in the vessels.

It's important to know! If a person has problems with bleeding gums, then for prophylactic purposes, the use of Etamsilat can be prescribed. In this case, you will need to contact a specialist and make sure that such therapy is rational.

In what cases is the use of the medication contraindicated?

The list of relevant contraindications to the use of Etamsilat is not significant. In this case, it is quite important to adhere to contraindications, otherwise, serious complications may occur. A number of such contraindications include:

1. Hypersensitivity to any component from the composition of the medication.
2. Hemoblastosis in childhood.
3. Acute porphyria.
4. Thromboembolism.
5. Thrombosis.

It's important to know! With any of the above contraindications, it is prohibited to use the drug Etamzilat. If the doctor prescribes the use of the drug, then the patient must report the presence of contraindications.

The use of the medication Etamsilat

The dosage of the medication is calculated directly depending on the corresponding indications. Etamzilat can be injected intravenously or intramuscularly. The optimal dosage per day will be:

• For adults, the recommended dosage is 10-20 mg per 1 kg of body weight. The resulting dosage must be divided into 3 doses.
• For children, it is recommended to use the medication in a dosage of 10 to 15 mg per 1 kg of body weight. In this case, the resulting dosage must be divided into 3-4 applications.

In addition, in the event of external damage to the skin, veins or capillaries, you can use the medication by applying a sterile swab soaked in advance in the composition of the medication. It is also allowed to take medication in the form of drops for instilling the eyes.

During pregnancy, Etamsilat injections can be used, but in case of an emergency need. The safety of using the medication during pregnancy has not been studied, so complications may occur. You cannot use the medicine at the same time as breastfeeding.

Directions for using the medication

To exclude the occurrence of complications and side symptoms, it is required to monitor the recommendations for the use of the medication. Some of these recommendations include:

1. It is prohibited to use the medication as the only therapeutic agent for signs of bleeding and effusion in a patient.
2. If the patient has signs of the formation of blood clots inside the vessels, as well as when the blood vessels are clogged, then the use of medication should be taken with extreme caution.
3. When bleeding occurs in a variety of organs associated with an overdose of blood thinners, it is required to use drugs that help regulate metabolic processes.
4. It is forbidden to administer the medication in the form of an emulsion with other means, except for the solvent.

Summing up, it should be noted that after the use of the drug Etamsilat, it is possible to develop side symptoms, manifested in the form of migraines, dizziness, decreased pressure and burning sensation in the chest. If side symptoms occur, you need to consult a specialist. You can store the product at a temperature not higher than +25 degrees.

Waiting for a baby is definitely associated with tender and pleasant feelings. Every woman during this period tries to treat her health with special responsibility so that the baby develops normally and is born on time. However, sometimes pregnancy is accompanied by quite serious problems and causes a lot of worries for the expectant mother.

Trouble often occurs in the early stages of gestation. At this stage, pregnancy can be complicated by uterine bleeding, which indicates abnormalities in the development of the placenta and creates a threat of miscarriage. Etamsylate is one of the drugs that help women keep a baby. How to use Etamsilat correctly during pregnancy?

Indications for the use of solution for injection

What can Ethamsilat help from? The drug has a wide range of indications for use. This drug helps to reduce blood loss and prevent anemia. The instructions say that Etamsilat is prescribed in such cases:

• bleeding of various etiologies;
• uterine bleeding;
• profuse menstrual blood loss;
• dental surgery (removal of a cyst or tooth);
• eye surgery (cataract removal);
• urological surgery (prostatectomy);
• traumatic injuries with capillary bleeding;
• microsurgery in otolaryngology;
• internal bleeding;
• cerebral hemorrhage;
• polymenorrhea;
• nosebleeds with increased pressure;
• hemorrhagic diathesis;
• vasculitis (we recommend reading: how is hemorrhoidal vasculitis treated in children?).

Instructions for use

When a doctor diagnoses a pregnant woman with a threat of miscarriage, she is prescribed Etamsilat in injections. The drug, available as an injection, is used for intramuscular or intravenous administration. When used intravenously, the solution must be injected slowly. The effect of the drug is felt 5 minutes after administration, and after 1.5 hours its maximum effect is observed.

The instructions do not contain instructions regarding the dosage and duration of treatment during the period of gestation. For this reason, the treatment regimens recommended by the doctor should be strictly followed. The solution does not need to be diluted with water for injection, since sodium chloride is already included in the ampoule.

In some cases, the optimal effect is achieved by combining injectable and tablet forms of the drug. Usually, injections are used for emergency help, and then the patient is prescribed another course of taking Etamsilate in tablets.

The daily dose of the solution for adults should not exceed 10-20 mg / kg of body weight. This amount is divided into 3 or 4 injections during the day with an interval of 6-8 hours. For children, the indicated amount of the substance should be halved.

In preparation for surgical manipulations, 1-2 ampoules of Etamsilate are injected into a muscle or vein. The same dose is given intravenously during surgery. If, after surgery, there is a risk of bleeding, then the person is given Etamsilat injections, observing an interval of 6 hours.

For newborns, the drug is allowed to be administered intramuscularly. The dose is calculated based on the child's body weight. It is recommended to inject 12.5 mg of solution per 1 kg of weight. The therapy is carried out in the first 2 hours after birth.

Contraindications and side effects

When a pregnant woman has bleeding, her doctor will give her Etamsilate injections to preserve the fetus and avoid miscarriage in the early stages of pregnancy. However, this medication has a number of contraindications, so it cannot be prescribed for some women. It is forbidden to use Etamsilat if the patient has the following pathologies:

• thrombosis;
• high vascular permeability;
• individual sensitivity;
• blood diseases.

Special attention is required when the drug is used during the period of fetal formation, when its organs are laid. The dosage is determined only by the attending physician, an independent change in the recommended dose can cause serious harm to the baby.

Sometimes, after the injection of Etamsilat, side effects are observed that negatively affect the condition of the pregnant woman. Side effects are most often manifested in the form:

• lowering blood pressure;
• disruption of the heart and blood vessels, thromboembolism;
• allergic reactions, swelling, rashes;
• headaches and dizziness;
• an increase in temperature;
• spasm of the bronchi.

If unpleasant symptoms appear after the administration of the drug, the doctor must be notified. He will adjust further treatment and replace Etamsilat with a drug with a similar effect, but with a different composition.

Etamsylate during pregnancy and breastfeeding

Usually, gynecologists prescribe Etamsilat in the first trimester of pregnancy, when there is a threat of miscarriage or chorionic detachment. Such pathological processes are evidenced by the patient's complaints of spotting or uterine bleeding. Before prescribing a medicine, the doctor must carefully examine the woman to assess her condition.

During pregnancy, it is necessary to be very careful with the appointment of any medication. Etamsilat is no exception. Injections are given only in case of urgent need. There are relatively few data on the effect of the drug on the developing fetus in the womb, and its use is sometimes necessary to maintain pregnancy. In newborns whose mothers were treated with Etamzilat in the first months of pregnancy, there were no developmental abnormalities.

In the later stages of pregnancy, this drug is not dangerous. For each patient, the doctor individually determines the need to use the drug and its dosage, taking into account the condition of the pregnant woman and the indicators of her analyzes.

Nursing mothers are not given Etamsilat injections. This is due to the penetration of the active substance of the drug into milk. If there is an urgent need to use Etamsilat solution, then the woman should stop breastfeeding and transfer the baby to artificial nutrition.

Analogues and price

The price of Etamsilat in the form of a solution for injection varies from 100 to 120 rubles, depending on the region and the type of pharmacy. If the patient is diagnosed with one of the conditions in which Etamsilat is contraindicated for use, then it can be replaced with one of the drugs with similar properties. If you need to replace the drug, you need to consult a doctor who will help you choose the best analogue. Medicines presented in the table have a similar effect.

Trade name	Active ingredient	Release form	Limitations	Features of use during pregnancy
Dicinon	Etamsilat	Pills	Age up to 3 years, lactose intolerance, thromboembolism, individual sensitivity	Can be used during pregnancy
Tranexam (see also: how to use Tranexam during pregnancy?)	Tranexamic acid	Solution for intravenous administration, tablets	Hemorrhage in the subarachnoid space, the threat of thrombosis, renal failure, pathology of color perception	Used to prevent uterine bleeding
Cyclonamine	Etamsilat	Tablets, ampoules with solution	Hemorrhages caused by taking drugs that inhibit blood clotting	It is used for bleeding, the threat of miscarriage
Vikasol	Menadione sodium bisulfite	Tablets, solution for intramuscular injection	High blood clotting rates, thrombosis, hemolytic disease	The last trimester of pregnancy in order to prevent hemorrhagic conditions in newborns (see also: late hemorrhagic disease in newborns).

Content

The hemostatic drug Etamsilat is used for the prevention and treatment of bleeding in surgery, gynecology, and other medical fields. It is prescribed for women with menstrual irregularities, to reduce profuse blood loss during menstruation. The appointment of the drug and the selection of its dosage form, regardless of the diagnosis and symptoms, should be carried out by the attending physician.

Instructions for the use of Etamzilat

The hemostatic (hemostatic) agent Etamsilat is characterized by angioprotective, proaggregant actions. The drug stimulates an increase in the rate of platelet development and their release from the bone marrow. It is used to stop and prevent capillary and parenchymal bleeding, diapedetic hemorrhage, in surgery, gynecology, ophthalmological, dental, urological and otolaryngological practice during surgical interventions.

The hemostatic effect of the drug Etamsilat is due to the formation of thromboplastin at the site of damage to the vessel and a decrease in the formation of prostacyclin in the vessel walls, which leads to stopping or reducing bleeding. The antihyaluronidase activity of the main component prevents the destruction of mucopolysaccharides of the capillary walls, increases their resistance and reduces fragility. Taking the drug does not have a vasoconstrictor effect, does not contribute to thrombus formation.

Composition and form of release

The drug Etamsilat is available in two dosage forms - tablets for oral administration and a solution for intramuscular or intravenous injections. White tablets of convex shape contain 250 mg of the main active ingredient (sodium ethamsylate) and auxiliary components (sodium hydrogen phosphate dihydrate, sodium metabisulfite, povidone, potato starch, calcium stearate). Packaged in blisters of 50 or 100 pieces.

Solution for injection Etamsylate is a clear, colorless or slightly yellow liquid. Packaged in ampoules of 2 ml, 1.2 or 10 ampoules per pack. Content of active and auxiliary components of the solution:

Pharmacodynamics and pharmacokinetics

The active component of the drug - sodium etamsylate - promotes the formation of mucopolysaccharides and thromboplastin, providing the hemostatic activity of the agent. Taking the drug helps to normalize the rate of blood coagulation, increase the elasticity and stability of the capillary walls, reduce their permeability, and improve microcirculation processes. At the same time, the prothrombin time (blood clotting time) does not change, normal platelet adhesion (adhesion rate) is restored, and the hypercoagulable effect does not appear.

When administered intravenously or intramuscularly, the therapeutic effect begins after 10 minutes, the maximum effect occurs after 2 hours with a duration of 4 to 6 hours. When taken orally, the rate of onset of positive dynamics is lower, while the hemostatic indicators are better. Regardless of the method of administration, about 72% of the dose taken is excreted in the bile, excreted in the urine throughout the day after administration.

Indications for use

The drug is used to treat or prevent capillary bleeding during surgery or in emergency cases and diseases with concomitant symptoms (risk of bleeding). Indications for use are:

• diabetic angiopathy;
• hemorrhagic diabetic retinopathy;
• hemorrhagic diathesis;
• von Willebrand-Jurgens syndrome;
• hemorrhagic vasculitis;
• diapedesis;
• hematuria;
• polymenorrhea (menstruation with profuse blood loss, menstrual irregularities).
• surgical interventions in otorhinolaryngology (tonsillectomy, microsurgical operations on the ear);
• ophthalmic surgery (anti-glaucomatous surgery, retinal surgery);
• dental operations (removal of cysts, granulomas, tooth extraction);
• urological operations;
• gynecological practice (for operations on abundantly blood-supplied tissues)
• with acute intestinal or pulmonary bleeding.

Method of administration and dosage

The duration of the course of treatment with the use of Etamsilat, the regimen and form of administration, the volume of a single and daily dose are determined by the attending physician, depending on the diagnosis and symptoms. The dosage recommended by the instructions for use is:

• when taken orally: 250-500 mg 3-4 times a day (a single single dose for oral administration is increased to 750 mg if indicated);
• intramuscularly or intravenously: 125-250 mg, 3-4 injections per day;
• for parenteral administration: up to 375 mg;
• in childhood: 10-15 mg / kg per day, 3 injections per day, in equal doses.

Oral administration of the drug is prescribed for the treatment and prevention of bleeding in diabetic microangiopathies and diathesis. Etamsylate for heavy periods and for the treatment of cycle disorders is also recommended for oral administration. Possible treatment regimens:

• Metro and menorrhagia during menstruation and treatment of dysfunctional uterine bleeding - 0.5 g once every 6 hours, the course of treatment is 5-12 days. Prophylactically - 1 tablet 4 times a day on bleeding days, and during the next two days of the cycle.
• Diabetic angiopathy - 1-2 tablets 2-3 times a day, duration of treatment 2-3 months.
• Prevention of the risk of postoperative bleeding - 6-8 tablets per day with an even distribution of doses for each dose for 24 hours.

Etamsilate in ampoules

Etamsilat injections are used to prevent bleeding before and after surgery if indicated (2-4 ml intramuscularly or intravenously, one hour before surgery). If there is a risk of postoperative bleeding, appoint 4-6 ml per day. Possible application schemes:

• hemorrhagic diathesis - 1.5 g, one injection per day, course duration 5-14 days;
• in ophthalmology - 0.125 g (1 ml of solution) subconjunctivally or retrobulbar;
• in veterinary practice - 0.1 ml for each kilogram of animal weight 2 times a day.

Etamsylate during pregnancy

During pregnancy Etamsilat is prescribed with caution. Use during the first trimester is not recommended. With the appearance of spotting or the threat of miscarriage at a later date, it is used in combination with Progesterone with constant monitoring of blood clotting. The appointment should be made by a doctor leading a pregnancy, self-medication can lead to negative consequences for the health of the mother or fetus.

Drug interactions

It is unacceptable to mix Etamsilate solution in one syringe with other medications. With parallel therapy with a pharmaceutical group of dextrans, with the introduction of the drug at a dosage of 10 mg / kg one hour before their intake, a decrease in the antiplatelet effect is possible; the introduction after does not have a pronounced hemostatic effect. Joint use with aminocaproic acid, menadione sodium bisulfite is permissible.

Side effects and overdose

The course of treatment with the use of Etamsilat in most cases is well tolerated, provided that the treatment regimen and daily dosage are observed. No cases of overdose have been reported, with complicated bleeding caused by an overdose of anticoagulants, the use of specific antidotes is indicated. Possible side effects of taking the drug:

• a feeling of discomfort or burning in the chest area;
• heartburn;
• stomach pain;
• anemia;
• decrease in intracranial pressure;
• hyperemia of the skin of the face;
• headache and dizziness;
• arterial hypertension;
• lowering systolic blood pressure;
• paresthesia of the skin (numbness, tingling sensation) of the lower extremities.

Contraindications

Appointment of the drug Etamsilat is not indicated for diseases and conditions with concomitant increased thrombus formation. The instructions for use include contraindications for admission:

• thromboembolism;
• thrombosis;
• hemorrhage while taking anticoagulants;
• increased blood clotting;
• acute porphyria;
• bronchial asthma;
• hemoblastosis in children;
• hypersensitivity to drug components.

Terms of sale and storage

Etamsilate is available in pharmacies by prescription. It is necessary to store the product out of the reach of children, in a dark place, at a temperature not exceeding 25 ° C. Shelf life is two years from the date indicated on the package.

Analogs

The only registered complete structural analogue of the drug Etamsilat is Dicinone. When side effects appear or individual intolerance is identified, the replacement is made by the attending physician for one of the following drugs:

• Dicinon;
• Vikasol;
• Ezelin;
• Methylergobrevin;
• Tachocomb;
• Impedil;
• Gordox;
• Tranexam;
• Altodor.

Etamzilat's price

You can buy the drug Etamsilat at a pharmacy or on specialized Internet resources by ordering home delivery. Average cost of all forms of release.

Few facts about the product:

Instructions for use

Price in the online pharmacy website: from 125

Few facts

Etamsylate is a capillary-protective drug that has a hematogenous effect. Used for the prevention of capillary hemorrhage. It is prescribed for the surgical treatment of urological, gynecological, ophthalmological and dental diseases.

The hemostatic solution is produced by the Russian company PharmFirma SOTEX. In September 2011 it was entered into the register of medicines. Has pronounced capillaroprotective and antihemorrhagic properties. It is used in ophthalmic, dental, urological, gynecological and cardiological practice to prevent bleeding of various etiologies. It can be used in the treatment of diseases caused by diabetes mellitus: hemorrhagic form of retinopathy, diabetic hemophthalmus, etc.

Dosage form and biochemical composition

The most common form of Etamsilate release is a cream-colored injection solution. The composition of 1 ml of medicinal liquid includes:

• etamsylate (125.0 mg);
• purified water for infusion;
• sodium pyrosulfite;
• disodium salt;
• sodium sulfite.

12.5% \u200b\u200bhemostatic solution is poured into 2 ml ampoules. The carton can contain 10 or 50 ampoules along with detailed instructions for the use of the medicinal product.

Therapeutic activity

The drug has a capillaroprotective, antihemorrhagic and hemostatic effect. Active substances stimulate the synthesis of mucopolysaccharides in the walls of arterioles and venules, in connection with which their elasticity increases and permeability decreases.

The hemostatic effect is due to the increased production of thromboplastin in the body. When using the solution, the production of blood coagulation factor III is accelerated, which improves the adhesion of blood plates. The drug does not have hypercoagulable activity, and also does not stimulate the formation of blood clots inside the capillaries.

Conditions for prescribing a medication

The agent is prescribed for stopping and preventing hemorrhages during surgical interventions and diabetic angiopathies. Indications for the use of hemostatic solution are:

• ear microsurgery;
• tooth extraction;
• hemorrhagic diathesis;
• antiglaucoma operations;
• cataract resection;
• prostatectomy;
• gynecological operations;
• pulmonary hemorrhage;
• parenchymal bleeding;
• fibroids;
• nosebleeds;
• intracranial injury;
• diabetic retinopathy.

An angioprotective drug can be used to improve blood circulation in the vessels and increase their mechanical stability.

Dosage regimen

Etamsylate is intended for parenteral (intramuscular, retrobulbar, intravenous) administration. The recommended dose of the solution for the prevention of blood loss during surgery is 2 ml or 4 ml. The medicine is administered 50-60 minutes before surgery. With reduced blood clotting, the dosage is increased or the solution is injected again during a surgical operation.

With capillary hemorrhages, 4 ml of a hemostatic agent is prescribed. Then, every 6 hours, an additional 1 ampoule of solution is injected. The hemostatic effect appears within 15 minutes after the drug is administered. The duration of therapy depends on the rate at which the bleeding stops.

With hemorrhagic diathesis, treatment is carried out in courses of 10-14 days. The standard dosage of the medication is 0.25 g at least 2 times a day. With the improvement of the patient's well-being, they are transferred to oral administration of hemostatic drugs.

Use during pregnancy

During pregnancy Etamsilat is prescribed solely according to indications. The teratogenic activity of the drug has not been identified, therefore, it is believed that parenteral administration of the solution does not in any way affect the intrauterine development of the fetus.

Alcohol compatibility

It is undesirable to drink alcohol while taking the medicine, because it has anticoagulant properties.

Overdose and side effects

The instruction does not contain data on an overdose of a medicinal solution. Theoretically, a temporary deterioration in well-being associated with changes in hemodynamics is possible. This may be evidenced by skin hyperemia, weak systolic pressure, etc.

In most cases, the use of a hemostatic agent does not cause side effects. In isolated cases, patients complain of:

• heartburn;
• paresthesia of the limbs;
• impaired coordination of movements;
• heaviness in the epigastrium;
• increased sweating.

The occurrence of the listed symptoms is the basis for refusing to continue therapy.

Interaction with medicines

The medicine cannot be combined with other medicines for infusion, except for the solvent.

Contraindications

It is necessary to use Etamsilat with caution in persons with impaired blood coagulability and a history of vascular pathologies. Contraindications to the appointment of a drug will be:

• osteosarcoma;
• embolism;
• lymphatic leukemia;
• myeloid leukemia;
• acute porphyria;
• hemorrhages caused by anticoagulants;
• allergy to sodium sulfite.

Angioprotective and hemostatic drugs are not prescribed for increased blood clotting, as well as hemoblastosis in children.

Analogs

Etamsylate can be replaced with agents that have hemostatic and capillary-protective activity:

• Dicinon;
• Cyclonamine;
• Vikasol;
• Aprotex;
• Trenax.

Terms of sale and storage

The solution for infusion is dispensed in pharmacy chains by prescription. It should be stored in a place protected from the sun at a temperature of 16-24 degrees Celsius. The drug has a maximum shelf life of 3 years. If the liquid becomes cloudy or precipitates out, ampoules are not used for parenteral administration.