How does metformin work on the human body? Its side effects and contraindications. View Full Version How to Stop Metformin When Pregnant

Metformin hydrochloride (metformin)

Composition and release form of the drug

Film-coated tablets white, oblong, biconvex, with a line on one side; cross-section - a homogeneous white or almost white mass.

Profile adverse reactions in children aged 10 years and older is the same as in adults.

Drug interactions

With simultaneous use with sulfonylurea derivatives, acarbose, insulin, salicylates, MAO inhibitors, oxytetracycline, ACE inhibitors, with clofibrate, cyclophosphamide, the hypoglycemic effect of metformin may increase.

With simultaneous use with corticosteroids, hormonal contraceptives for oral administration, danazol, epinephrine, glucagon, thyroid hormones, phenothiazine derivatives, thiazide diuretics, derivatives, the hypoglycemic effect of metformin may decrease.

In patients receiving metformin, the use of iodine-containing contrast media for the purpose of diagnostic research (including IV urography, IV cholangiography, angiography, CT) increases the risk of acute renal dysfunction and lactic acidosis. These combinations are contraindicated.

Beta 2 -adrenomimetics in the form of injections increase the concentration of glucose in the blood due to stimulation of β 2 -adrenergic receptors. In this case, it is necessary to control the concentration of glucose in the blood. Insulin is recommended if necessary.

Concomitant use of cimetidine may increase the risk of lactic acidosis.

The simultaneous use of "loop" diuretics can lead to the development of lactic acidosis due to the possible functional renal failure.

If taken simultaneously with ethanol, the risk of developing lactic acidosis increases.

Nifedipine increases the absorption and C max of metformin.

Cationic drugs (amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) secreted in the renal tubules compete with metformin for tubular transport systems and can lead to an increase in its C max.

special instructions

Do not use before surgical operations and within 2 days after them.

Care should be taken to use metformin in elderly patients and those performing heavy physical work, which is associated with an increased risk of developing lactic acidosis. In elderly patients, asymptomatic renal dysfunction is often observed. Particular care is required if renal dysfunction is triggered by taking diuretics or NSAIDs.

If, during treatment, the patient has muscle cramps, indigestion (abdominal pain) and severe asthenia, then it should be borne in mind that these symptoms may indicate the onset of lactic acidosis.

During the period of treatment, it is necessary to monitor kidney function; the determination of the lactate content in the plasma should be carried out at least 2 times a year, as well as when myalgia appears.

When metformin is used as monotherapy in accordance with the dosing regimen, hypoglycemia usually does not occur. However, when combined with insulin or sulfonylurea derivatives, there is a risk of hypoglycemia. In such cases, it is necessary to especially carefully monitor the concentration of glucose in the blood.

During the period of treatment, patients should avoid drinking alcohol because of the risk of developing lactic acidosis.

Preclinical studies have shown that metformin has no carcinogenic potential.

Pregnancy and lactation

There have been no adequate and well-controlled studies on the safety of metformin during pregnancy. Use during pregnancy is possible in cases of extreme necessity, when the expected benefit of therapy to the mother outweighs the possible risk to the fetus. Metformin crosses the placental barrier.

Metformin in small quantities is excreted in breast milk, while the concentration of metformin in breast milk can be 1/3 of the concentration in the mother's plasma. Side effects were not observed in newborns with breastfeeding while taking metformin. However, due to the limited amount of data, use during breastfeeding is not recommended. The decision to stop breastfeeding should be made in the light of the benefits of breastfeeding and potential risk the occurrence of side effects in a child.

Preclinical studies have shown that metformin does not have a teratogenic effect in doses that are 2-3 times higher than the therapeutic doses used in humans. Metformin has no mutagenic potential, does not affect fertility.

With impaired renal function

Contraindicated in severe renal impairment.

For violations of liver function

Contraindicated in severe liver dysfunction.

Use in the elderly

04.07.2003, 21:25

Can you please tell me if it is possible to take Metformin during pregnancy? The endocrinologist prescribed it to me to lower the level of DHEA-s (in my opinion, that's the name), which exceeded the norm by several times. After using Metformin, all indicators returned to normal.

I received a positive result after IVF, the doctor said not to cancel it on the protocol and in the waiting process because of its relative harmlessness, but about "later" - I forgot to ask him. Found it on the list of relatively safe during pregnancy, but I'm very worried.

Give up or keep taking?

Thanks in advance for your reply!

Precinct

05.07.2003, 00:52

The answer to your question depends on how necessary it is to continue the treatment. Animal studies have shown the safety of metformin, but no human studies.

What do you treat with metformin, polycystic disease? The IVF doctor appears to be literate because it is a comparatively newer insulin suppression treatment. We do not know what the risk of metformin in pregnancy is, but we do know that diabetes in pregnancy is dangerous for the fetus. This is the benefit.

Ask your doctor. Only he can weigh all the pros and cons.

10.07.2003, 09:12

Thank you for the answer! I have neither polycystic disease nor diabetes (TTT 1000 times !!!). I am now in the States, and an endocrinologist prescribed me Metformin, having seen the excess of DHEA in the analyzes several times. And that's all. I also drink dexamethasone 0.5 tablets a day.

What do you think, if these 2x are not insidious diseases, can I do without Metformin during pregnancy? :) :) The doctors here are still the same, I trust our relatives more :)

Thank!

10.07.2003, 11:36

You need to stop taking Metformin.

Precinct

13.07.2003, 08:08

I would clarify, Bukycuk, whether your doctor is treating polycystic disease. He doesn't necessarily say the words "Polycystic Ovarian Syndrome". Ask. You can call the doctor and leave a message on the answering machine: your name, your phone number and the question: "Do I need to continue taking Metformin? Do I have polycistic ovarian Syndrome?"

In vitro fertilization, high DHEA, dexamethasone treatment, metformin normalizes DHEA.

What do you think, Yakov, is another diagnosis possible here?

What does the research show? If a patient with polycystic disease stops taking metformin in the first trimester, how much will the chance of miscarriage increase as a percentage? What is the danger to the fetus?

13.07.2003, 12:29

Currently, there are a number of works on the use of metformin during pregnancy (this topic was discussed in our DC here ([Links can only be seen by registered and activated users])). But until sufficient experience of such use has accumulated, I am of the opinion that the drug should be canceled when pregnancy occurs, especially if there are no special indications for this, which I do not see in this message. Of course, it is best for the patient to finally resolve this issue with the attending physician.

Precinct

13.07.2003, 15:39

I completely agree with you, not knowing the laboratory data, not seeing the history of IVF, and most importantly, not knowing the diagnosis, advise the patient about treatment ... um. carelessly. A doctor is needed here.

I would like to clarify one point. With polycystic disease, the chance of fetal death is quite high and metformin can reduce it.

What is its danger?

13.07.2003, 17:07

Dear "District"!
Unfortunately, I do not have time to enter into medical discussions on the forum, and I only answer specifically questions asked patients. Sorry.

Precinct

14.07.2003, 07:18

Sorry, I didn't mean to distract.

You don't have to answer.

14.07.2003, 11:16

Uv. Precinct!

In our country, metformin is not registered for use by pregnant women.

That is, the real situation looks like this: in the annotation to the drug in the section "contraindications" it is indicated that such a contraindication for taking the drug is pregnancy and breastfeeding, in addition, you should stop breast-feeding when using metformin.

I can agree with you that this is from a series of what is called "overdoing", but a doctor cannot and should not exceed his authority and recommend a drug that has not passed registration and is not allowed for use by pregnant women. As I understand it, there is no question of permission from the ethics committee at all ...

Precinct

14.07.2003, 15:05

Here's your answer, Bukycuk.

"...not registered..."
"... authority ..."
"...the committee..."

14.07.2003, 16:36

I appreciate the great depth of your sarcasm.

Disregard for orders - for you a rule or a game on the forum?

And, really, for this lady, whom you have not seen in the eyes and do not know absolutely anything about her problems, and who, for example, will be tempted by your self-confidence, and will take the drug, the course of pregnancy, let's say correctly, will be difficult? You will undertake to explain that, they say, there are articles ... women accepted ...

Do you have any other arguments?

Precinct

14.07.2003, 18:21

Tatyana, least of all I wanted to offend you. I'm sorry.

Please understand my point:
I did not recommend our patient to continue or discontinue metformin. Again: I did not recommend our patient to continue or discontinue metformin.

This is because I do not know the diagnosis. Are you sure she has polycystic disease? Yes, the description of the treatment and other details strongly indicate this diagnosis, but there can be no certainty. Information is limited. I gave and continue to insist on the advice not to stop any treatment without permission.

But I am sincerely worried about your arguments for stopping treatment. Treatment for what, Tatiana?

Okay, let's pretend it's polycystic. Metformin has shown that it can save the life of the fetus (I will present evidence if required). Then if you, Tatyana, advise our patient to stop metformin, then the question arises, how dangerous is it for the fetus? If it saves the life of the fetus, then what is its danger? This is not my question. I am sure, 100%, this is a question of our patient.

Any sane person who is denied a cure for a deadly disease will ask: why is it dangerous to me?

And then your arguments, Tatiana, appear:

1. "in our country, metformin is not registered for use by pregnant women."

2. "That is, the real situation looks like this: in the annotation to the drug in the section" contraindications "it is indicated ..."

3. "this is from a series that is called" to override "

4. "a doctor cannot and should not exceed his authority"

5. "As far as I understand, there is no question of permission from the ethics committee at all ..."

Is it about the possible danger to the fetus in the first trimester? Or mortal danger to the doctor?

What are my counterarguments?

Your first argument. (see above). The patient is not in Russia.

2. If there is no evidence of serious harm, but there is evidence of benefit, then the annotation is sent to the toilet. (I repeat, patient abroad)

3. I can't find any counter-arguments. Something I'm confused. Whose argument is this? Mine or yours?

4. Abroad.

5. Abroad.

Please don't take this personally, Tatiana. I have seen your statements in other conversations. You are a highly erudite Doctor. I just don't think those arguments are a reason to tell the patient "stop using metformin"

14.07.2003, 20:18

I stopped taking Metformin. The endocrinologist prescribed it to me only to regulate the DHE-A hormone, I have never had any polycystic disease in my life.

Brief history: in 2001, there was a laparoscopy, where they found a small number of external genital endometriosis, which was cauterized. There were no other problems. The doctor who performed IVF for us diagnosed "inexplicable" infertility, because in his opinion, such a minor endometriosis does NOT affect conception, the husband is doing well. IVF was done in St. Petersburg, we temporarily live in the States.

An endocrinologist (American) deals mainly with diabetes, this can explain the appointment of Metformin.

Thank you all very much!

14.07.2003, 21:05

I am grateful for your understanding, and I do not even exclude that some of the ideas are sympathetic to you and I will note between us - I was not offended. Rather, we have different points of view - and this is not a reason for emotions.

And we really faced the realities of Internet consulting: we do not have the opportunity to obtain a sufficient amount of information, and the differences in the registration of drugs in different countries may be.

But this is not even the point: can you explain to me what is the connection between PCOS and a high content of exclusively DHEA?

It is no secret that PCOS - a certain% of women with excess insulin - insulin resistance - an even greater increase in IRI - influence on the development of follicles - hyperandrogenism - all in a complex and as a result anovulation and infertility. Sensitizer Metformin has the right to be.

But there are also works where data is given that when taking metformin with children everything is OK (children up to one year of age are traced), not everything is so smooth in mothers: during pregnancy, preeclampsia is several times more common.
That is, not all issues have yet been resolved to be sure of the absolute safety of taking Metformin. But if, for one reason or another, you think that the arguments for the favor significantly outweigh those that are against, it is worth providing the woman with information in an accessible form, leaving her the right to choose.

But back to the treatment: are you right treating what? Not the fact that there is PCOS at all.

14.07.2003, 22:28

I didn't immediately see the message from uv.Bukycuk, we started writing texts almost simultaneously, and I was distracted ...

So, if it's not about PCOS / T2DM, how can Metformin help?

Precinct

15.07.2003, 03:33

What do you think, Tatyana, why was DHEA increased and why did metformin lower it?

15.07.2003, 10:01

I admire your pedagogical gift, but maybe you shouldn't readdress the question?

Have you thought about the situation as a simple laboratory error? In my practice, this is not exclusive, no one is immune from mistakes.

15.07.2003, 10:19

Tatyana!
I beg your pardon for interfering. But maybe it is worth clarifying what was still determined in Bukycuk, dehydroepiandrosterone (DHEA) or DHEA-sulfate? And what does “exceeding DHEA by several times” mean, what is the specific concentration in figures? The physiological spread of the DHEA - SO4 concentration range is very wide. For example, I would not mind if the concentration of this hormone was at the upper limit of the norm.;) And how is Bukycuk with weight?

Respectfully!

Precinct

15.07.2003, 13:51

You are right, no one is immune from mistakes. If we compare the chances of a laboratory error with the chances of a correct result, then, fortunately, the latter are incomparably higher. Especially in a woman with difficulty getting pregnant after IVF treatment with dexamethasone. It seems to me that true adrenal hyperproduction is more likely.

Although in doubt, it's always easy to double-check.

15.07.2003, 14:50

I think that there are facts for congenital dysfunction of the adrenal cortex, but knowing the manic passion of my colleagues to prescribe dexamethasone (a word that is so beautiful? - because these actions have no logical explanation ...) I am not so sure of this.

So what we have:
1.increased DHEA content - a marker of adrenal androgen hyperproduction (there is no clear data, how many times has the study been conducted?). But another marker, 17 oxyprogesterone, has not been investigated.
2. Infertility + IVF (with adequate therapy of VDKN, IVF is not necessary)
3. There is no evidence of excess testosterone, and it is not a fact that it should be.
4. When i.e. At what age was dexamethasone prescribed?

Bukycuk can answer any questions.

I must say that the topic of prescribing "dexamethasone to a heap" for all women with infertility has already crossed all reasonable limits, and no explanations help ... Already at the level of a conditioned reflex, it is prescribed ... Maybe the name of the drug should be changed to a less "cute" one? : p

15.07.2003, 15:02

Vladimir Yakovlevich!

I understand your personal attachment to DHEA-S, but for the female sex, the excess content of this hormone - (like 17-OR) - is a marker of adrenal malfunction, one of the manifestations of which is hyperandrogenism and infertility. And an increase in DHEA-S several times can talk about this ...

15.07.2003, 18:58

Dear Tatiana!
Despite all the affection (as you put it) in men for DHEA-S, "improper adrenal work" for them in the direction of pathological amplification is also not a gift. After all, I just asked: “exceeding DHEA by several times”, how much is it? The lower and upper levels of the concentration of the hormone in the plasma normally differ by more than 5 times, and even more when determined in the urine. From what figure should the excess of DHEA-S be considered at times? From some average? Maximum?: Eek:
Or do specific values \u200b\u200blook less convincing?

Precinct

15.07.2003, 19:45

From the tips of the ears and up.

15.07.2003, 20:26

Silence is the most perfect expression of scorn.

Metformin is medicine with the active substance of the same name in the composition. The medication is produced by different manufacturers, but this does not change the scheme of its action.

The price of metformin in pharmacies varies and largely depends on the region of purchase, dosage and number of tablets in the package.

The price of Metmorphin Canon (60 pcs of 500 mg) is about $ 3, and Metformin Richter (60 pcs of 500 mg) will cost almost $ 4.

Despite the fact that the instruction for the use of Metformin does not give such data, the drug is compared with the drug universal action, which provides unique assistance to the body, relieving it of existing diseases and preventing the emergence of new ones.

The fact that Metformin prolongs life and saves from old age can now be heard from many patients.

The active ingredient of the drug is metformin hydrochloride. This name is international.

Analogs of Metformin are produced with the same active ingredient. The release form for all drugs is identical - tablets.

Original drug, like generics, has a positive effect on the human body:

• protects the brain from aging;
• prevents vascular and heart diseases;
• reduces the likelihood of the formation of oncological tumors;
• prevents osteoporosis in diabetics;
• positively affects thyroid gland;
• protects the respiratory system from negative actions.

With each study, new positive qualities of the drug Metformin are discovered. This allows many people to use it.

Initially, the mechanism of action of the drug will be determined as.

In other words, drugs containing metformin hydrochloride have been used to lower blood sugar levels, increase insulin sensitivity, and suppress liver glucose production.

Indications for the use of Metformin

The mechanism of action of Metformin is decisive in the collective analysis of the list of indications.

According to the instructions, the medication is used for and also for the prevention of this disease.

Tablets for diabetes mellitus Metformin are prescribed to people of all ages, including children from 10 years old.

Moving away from the instructions for use, you can find out that the medicine is used in gynecology, dietetics, reproductive medicine, cosmetology, angiology, gerontology, which once again proves its uniqueness and effectiveness.

special instructions

The use of Metformin obliges the patient to be regularly examined for renal pathologies and changes in blood counts.

According to the results, the treatment regimen can be adjusted by the doctor.

When conducting an X-ray using a contrast agent, you must refrain from using the drug for 2 days.

In case of bronchopulmonary diseases or pathologies of the urinary tract, the doctor must be notified. Perhaps a different dosage will be chosen for the further use of Metformin.

Metformin and alcohol are incompatible drugs, as alcohol can significantly lower blood sugar levels, which threatens serious condition the patient.

You can also not use preparations based on alcohol-containing liquids.

Drug interactions

The medicine Metformin for type 2 diabetes should be taken as directed by your doctor. The medication is also necessary for patients prone to this disease.

However, prevention and treatment can be carried out taking into account the use of other medicines.

Metformin reacts with chemicals to produce the following effects:

• and renal failure when combined with X-ray examination;
• maintains the risk of lactic acidosis when combined with ethanol, hypoglycemic agents and during fasting;
• when used with Danazol;
• reduces the effect when used with Chlorpromazine;
• requires dose adjustment when taken with neuroleptics and corticosteroids;
• reduces efficiency when used with injectable beta-adrenergic agonists;
• enhances the effect when used and Nifedipine.

Metformin's analogs

Pharmacological enterprises produce many substitutes for Metformin.

Some have a similar trade name, but are produced by different companies, while others are supplied to the market under different names:

• Metformin Richter;
• Metformin Canon;
• Metformin Teva;
• Siofor;
• and Glucophage Long;
• Formetin;
• Formin Pliva;
• Sofamet.

FAQ

The instructions for use attached to the drug Metformin describe in detail the indications, contraindications, side effects and the scheme of action when they occur.

Despite this, patients have a lot of questions that are not covered in the annotation. This is due to the latest results from the study of Metformin and its substitutes.

Does Metformin really prolong life?

If you use Metformin to prevent diabetes mellitus and at the same time control blood sugar levels, you can actually extend your life and maintain your health.

In addition, the drug has a beneficial effect on the state of blood vessels and the heart, and the functioning of the whole organism depends on them.

Metformin helps to strengthen bones, especially in women during menopause, when the amount of estrogen is greatly reduced. As a result, the formation of osteoporosis is prevented.

In the brain, the drug affects stem cells, promoting the birth of new neurons.

It helps strengthen memory, prevents brain aging and prolongs life.

It is important to follow the rules for taking Metformin for prophylaxis and use it in a dose of no more than 1000 mg per day.

In what dosages can Metformin be taken for prevention?

Metformin has contraindications: hypersensitivity, renal and hepatic failure, tissue hypoxia, alcoholism, lactic acidosis, pregnancy and lactation.

In these cases, use a medication for prevention it is impossible... The rest of the patients can drink Metformin, a medicine for old age, for the purpose of prevention.

It is recommended to consult with your doctor in advance to establish an individual dose. Typically, the course of therapy begins with 1000 mg per day, divided into 2-3 doses (you can split the whole tablet in half).

Is this medication necessary for prediabetes?

It is imperative to take a hypoglycemic agent with high risk the development of diabetes. It will help prevent the formation of a dangerous disease and improve body functions.

Treatment for prediabetes can be lengthy. Individual recommendations are made by the doctor based on the body's response and blood sugar levels.

How long (days, weeks, or months) should I take the tablets?

How long to take Metformin can only be determined by a doctor. For some patients, course use for a month or a year is sufficient.

Medical practice has recorded cases when a hypoglycemic agent was prescribed for life-long use, which significantly increased patient survival.

When using a medication, it is necessary to be interested not only in the duration of treatment, but also in the maximum dose.

During the day, it is permissible to use no more than 3 grams of the drug. This portion is the maximum and is prescribed only by a doctor.

Do I need a special diet while taking Metformin?

If you take Metformin for weight loss, then you must adhere to a diet. Cut back on fast carbohydrates.

However, you cannot starve, otherwise you will start from using the medication side effects.

The daily calorie content of products should be at least 1000 kcal. The priority is protein foods, healthy fats and complex carbohydrates, as well as fiber and vitamins.

Metformin, Siofor or Glucophage: which is better?

Often, patients wonder what is better to take: Glucophage or Metformin Richter for weight loss?

If you use a medication without a medical recommendation, then there is not much difference. These drugs are similar and interchangeable.

What are the analogues for chronic renal failure?

Due to the fact that the medication is contraindicated in case of impaired renal function, it should be replaced with medications approved for use in this condition:

• Galvus,
• Glidiab,
• Glurenorm
• or those prescribed by your doctor.

Can Metformin be taken by pregnant women with gestational diabetes?

Metformin is contraindicated during pregnancy. However, studies involving pregnant women have shown positive results.

As a result of using the medication, the expectant mother did not gain excess weight, and the child was born without a predisposition to diabetes.

The question of the possibility of using Metformin is decided individually.

So. Let's start with the fact that my periods appeared once every 3-6 months. persistent anovulation (according to ultrasound and BT graphs). according to the analyzes, progesterone is reduced (which, in principle, is natural with anovulation).

5 YEARS I could not get pregnant. drank different pills. and COC, pricked progesterone. constant tests for hormones. Ultrasound. checking pipes. result is ZERO. only weight gain. my last gynecologist (by the way, sensible) offered to make a lapar. cut the ovaries. it was in the spring of 2010. I was afraid, because I had an operation at the age of 17 and after it I got out about 2/3 of my hair in a year. and still have not recovered .. then I made up my mind and in December 2010 came for the direction. signed me up for July 2011.

and at this time I spent a lot of time on various forums and sites. I talked with the girls and one of them advised me to drink METFORMIN. like research by American scientists. I studied the Internet and decided for a couple of months all the same a medicine for the treatment of type 2 diabetes.

i started taking it in mid-May 2011 .. at that time I was collecting tests for the lapar .. 2 weeks before the planned operation I did not drink it. BUT at the hospital I was sent back home (I have asthma). told you need to be treated. and not thinking about children. it was horror. my only chance. how I sobbed.

i'll tell you right away. that my cycle has become 63 days. + already large. I scored on pregnancy and decided to start drinking METFORMIN again in order to at least restore the cycle. I drank it until about the end of September. the cycle became 30 days. then I got sick. went to the hospital and did not take him anymore. the cycle did not go astray. remained the same. according to the BT schedule, ovulation began to appear (O. MIRACLE). ...

I am also tormented by your "past sores".

no cycle, pregnancy does not occur (

tell us the scheme of admission, please!

i will be very grateful for the answer

Please write me a treatment regimen.

P.s. Ovulation was every month

Six people drink it in my environment and all under different indications

The first person to be prescribed this drug was my mother. Then I found out that my employee was drinking it, and now 4 more people among my friends take it. And all with slightly different indications. For example, my neighbor was prescribed it in complex therapy for serious liver problems.

This is a drug for a serious illness.

Girls, I'll tell you right away. do not drink them for weight loss! First of all, these are pills for people with diabetes mellitus and women with disabilities menstrual cycle... This drug was prescribed to me by an endocrinologist in connection with diabetes. This drug inhibits gluconeogenesis in the liver. I have been drinking it for 6 months.

cool

I was prescribed this drug by a doctor, I am delighted. All my life I struggled with weight, but after 40 it became harder to keep the weight normal. Increased sugar due to excess weight. Metformin Richter works from the first tablet. I absolutely do not want to eat.

Metformin when planning pregnancy reviews

Hope this is finally the correct diagnosis. There must be a reason! In three months I will become slender like a gazelle (not a bus) and pregnant-pregnant like. fish!

There is very little information on such violations on the forums. It seems that I am the only one Has anyone come across this?

the doctor suggested to me Siofor for weight loss (I complained that I quickly gained weight), but at the same time excluded planning while taking Siofor.

however, I stimulate ovulation, I don't know about spontaneous independent ovulation.

I hope it helps you.

I haven’t come to a planning meeting for a hundred years, I just came because of Metformin, I wanted to write about him to girls who have PCOS and PCOS syndrome. I'm just like that. and with the same diagnosis.

In general, I drank this Meformin (aka Siofor or Glucophage) for 3 months. Until he brought me the long-awaited B., but my gynecologist is very pleased with the result, because I started to have normal stimulation. Dominants clearly grow, 1 or 2 DF, no cysts. The achievement so far is in this, but for me it is a very big success! I drink it in a very small dose, because they also stimulate me for a minute. dose of gonadotropin drugs. Why do I ask where you live? I know that while in former countries LPG is not used in this diagnosis. Yes, and then they officially began to use it since November 2006, although clinical trials were started in 2003 with a smile * extinguishing turnips ”(I can be wrong).

For a long time I hesitated whether to start his course, I certainly know its true purpose, but my doctor convinced me that I should not be afraid, because at the onset of B., its reception immediately stops, i.e. he must help exactly ZB., this is where his role ends.

I noticed one more "plus" of him against the background of his reception and with stimulation, not to gain extra pounds! Before that, after each stimulation, I gained 1 kg. The weight is now stable.

At one time I dug up a good and interesting article about him, you can read on this site http://cironline.ru/articles/climax/menstrual/143/

And also on motherhood I found girls who, with this analysis on this drug, received their B., there are not so many of them, but still. Mostly they all live in Germany. My treatment scheme is very different from the “German” one, because some of them say that they should drink this drug even with the onset of B. I would not dare to drink it with B. but this is my purely personal opinion

But still, morally, this forum helped me make a decision about this course of treatment, you can read these stories http://materinstvo.ru/index.php?showtopic\u003d45622&st\u003d0 At least a little, but it inspires that the goal is not so and far away!

I hope it helps you.

My cycle decreased, although it was within normal limits. Old day, now 28.

We are all different and react to the same drugs in different ways. It is a pity that he did not help you fix the problem.

To avoid discomfort from taking Metformin, it must be taken with meals. There will be no nausea and dizziness.

There was a Temka on planning, it also contained interesting links. They wrote that they get pregnant right on metformin and even during pregnancy they continue to take it under the supervision of a doctor. I haven’t asked my doctor yet.

My doctor said that ovulation can recover on its own without stimulation only on metformin. Seeing how my cycle has decreased in a month, I believe in it

By the way, I asked her about losing weight. She said that if you need to lose weight, then it is still necessary to follow a certain diet - to exclude sweet, flour, fatty foods.

the increase in androgens in a woman can lead to insulin resistance. what is the mechanism - I don't know, but the point is that insulin is not fully utilized by the tissues of the body, and since insulin is needed, the so-called effect of hyperinsulinemia occurs, when more and more insulin is produced in order to somehow replenish the body's impossibility use insulin. the result is a vicious circle. the higher the AI, the more GI.

which, in turn, spur an increase in the level of androgens and the further development of the disease. it is not for nothing that one of the most important stages in the treatment of hyperandrogenism and hyperandrogenism is weight loss.

I absolutely agree with your doctor about this, this preparation was not invented for weight loss, but for the normalization of insulin in the body. Even if from taking it to reduce body weight, then after the end of the intake, the lost weight will return, and worse than that, it is possible that more than was lost if it was used exactly as an avenue for weight loss.

I will try to explain in my own words the concept of "insulin resistance", although it is not so simple, without using scientific terms.

Before explaining this concept, it is necessary to point out that it is related to insulin. This is a hormone and what it is responsible for, everyone probably knows, but again, this is a hormone that helps the body use glucose (sugar) in the blood as an energy source and is produced by the pancreas. And since in healthy people, skeletal muscles use about 75-80% of glucose. Naturally, there is a reaction of the body to this hormone.

And for myself, I'm trying to understand this chain from the point of view of converting carbohydrates into excess weight, in other words. I want to understand for myself how to compose food in order to lose weight at the same time, since I have to drink these pills.

It seems clearer.

In order. I don't have PCOS, I just have insulin resistance (I took sugar and insulin tests with a glucose load, the doctor then multiplied them and divided them into something). Excess weight with predominantly fat deposition around the abdomen is the first sign of I. I got to the endocrinologist, finding out the cause of infertility, or rather chronic anovulation. There was an excess in cortisol and androgens. All the doctors (gynecologist, neurologist, endocrinologist) unambiguously said - 10 kg off, and everything will be fine by itself. But not every excess weight is the road to infertility, namely hormonal, like mine. There are a lot of examples of obese women who have never had problems with B.. By the way, my weight is not 300 kg, but "only" 78 (height 168) I gained weight sharply a couple of years ago, my whole stomach is in stretch marks. Since then, she lost weight, but then she gained. No more than I threw off, but no less.

In general, I am now taking bromocriptine and Glucophage. G. at a dose of 1000 mg per day (for now; if I feel fine, in a week I will switch to 1500 mg for 3 months). Plus a change in diet - in short, you need to eat more carbohydrates, such as bread, especially with bran and all kinds of seeds, pasta, porridge. Reduce fat intake as much as possible, even drink milk not 6%, but 1.5! Eliminate sweets altogether! (but this is for me). In 4 days, 2 kg went very unexpectedly (these are difficult kilograms). Subject to the diet, the weight should not return.

can I have a couple of questions :? Why did they say to eat more carbohydrates and at the same time exclude sweets - simple carbohydrates?

why eat less fatty foods - weight is not accumulated from fat, but because of the imbalance in the consumption and processing of carbohydrates (I always thought).

and another point: is anovulation accompanied by changes in the ovaries?

That is, it is understandable why the doctor suggested lowering fats. Again, it is clear why sugar - simple carbohydrates are not healthy anyway.

But with porridge. Apparently the doctor believes that metformin does not seem to allow carbohydrates to be absorbed (like Xenical removes fats). I thought so too, then I realized that it was kind of wrong.

some nonsense. in my opinion.

porridge and pasta are full of ugbevodov, and in the same low-carb diets it is recommended not to eat either pasta or porridge.

i do not know. I went to look for information in the internet

Complex carbohydrates (polysaccharides) require more energy for breakdown than simple ones (sugar), plus bran and other vegetable fiber interfere with the rapid absorption of carbohydrates and fat, we have time to spend them.

Michelle, you need to eat more carbohydrates than fatty foods, in a ratio of 5: 1, I think, or even more, the doctor said. Naturally, it is not uncontrollable to devour carbohydrates and bread, I have a table of the so-called. UNITS OF BREAD - a conventional unit containing 12 g of carbohydrates, which is about the same as in a half 1 cm thick piece of bread or 3 tablespoons of pasta. My BMI norm is 13 XE and 10 fat units (50 g of fat).

Why so, I don't know, I myself have always believed that it is better to eat more protein and fat, excluding bread, potatoes and sweets (Kremlin diet - by the way, I lost weight in this way). Apparently, the whole point is in the specificity of metabolic processes caused by endocrine disease.

The bottom line is this. In terms of calorie content, three slices of bread are less caloric and carbohydrate than gingerbread, but you don't eat gingerbread, be sure to eat four pieces, and then add sausages to keep you full. Fiber - like a brush or a sponge, binds fats and removes them, and sugar is simply absorbed.